Deciphering the role of granule deformation and fragmentation for the tableting performance of some dry granulated powders

In this study, the question of how fragmentation and deformation granules during compression can be linked to tableting performance dry granulated powders is addressed. Granulated a systematically varied composition plastic brittle material were prepared by slugging thereafter compacted into tablets. The tablet's micro-structure, porosity, tensile strength assessed; moreover, relationships between Adams parameters τ0 α studied. pressure had limited effect on tablet porosity. However, they marked which from tablets composed deformed but otherwise preserved small granule fragments. strength, loss tabletability, lubricant sensitivity with parameters, indicating complex performance. properties mediated number average force intergranular bonds tablet.